Notice of Retraction: Ahimastos AA, et al. Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial. JAMA. 2007;298(13):1539-1547.
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چکیده
Theauthors suggested that biosimilar qualitymight be inconsistent over time and suggested that track-and-trace capabilities might encourage consistent quality. Product quality is tightly regulatedby theFDA, both for referencebiologics and biosimilars. Each batch of every biologic must meet predetermined release specificationsbefore it canbeused to treat patients. These tight regulatory requirements ensure product quality and consistency over time for all biologics.
منابع مشابه
Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial.
CONTEXT Aortic stiffness is increased in Marfan syndrome contributing to aortic dilatation and rupture, the major cause of premature death in this population. Angiotensin-converting enzyme inhibitors have been shown to reduce arterial stiffness. OBJECTIVE To determine whether perindopril therapy reduces aortic stiffness and attenuates aortic dilatation in patients with Marfan syndrome. DESI...
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2000;342:145–53. 3. EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomized, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362:782–8. 4. The PEACE Investigators. Angiotensin-conv...
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InReplyWeagreewithDrsRedingtonandCaldarone thatmany animal andhumanstudieshave shownthat a singleor few (≤5) short episodes of remote ischemic preconditioning (typically 5minutes of limb ischemia followed by 5minutes of reperfusion)areprotective formanyorgans (including theheart, brain, and kidney) with few reported adverse effects. However, few studies have examined the long-term effects of re...
متن کاملRationale and design of a randomized clinical trial (Marfan Sartan) of angiotensin II receptor blocker therapy versus placebo in individuals with Marfan syndrome.
BACKGROUND Recent studies have demonstrated that blockade of the angiotensin II type 1 receptor with losartan decreases aortic damage in an animal model of Marfan syndrome (a KI mouse model with a pathogenic mutation in the gene coding for fibrillin-1). AIMS To demonstrate a beneficial effect of losartan on aortic dilatation when added to optimal therapy in patients with Marfan syndrome. ME...
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a randomized controlled trial. Eur Heart J 2013;34:3491–3500. 12. Meijboom LJ, Groenink M, Van der Wall EE, Romkes H, Stoker J, Mulder BJ. Aortic root asymmetry in Marfan patients: evaluation by magnetic resonance imaging and comparison with standard echocardiography. Int J Card Imaging 2000;16: 161–168. 13. Burman ED, Keegan J, Kilner PJ. Aortic root measurement by cardiovascular magnetic reso...
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ورودعنوان ژورنال:
- JAMA
دوره 314 24 شماره
صفحات -
تاریخ انتشار 2015